I am gettting my Smarty and I am wondering what settings should i run

Depends on how you drive it....I'm running sw#7 on a stock tranny but not for much longer...got a new one coming soon

I would say sw#3

Im getting my sbc 3250 DD on thursday also.

After your clutch is broken in I suggest you start with the lower levels on the odd numbers such as 3 or 5 then work your way up from there. The odd numbered programs have the advanced timing and the even do not. Watch your fuel pressure on the higher levels as on the stock pump I was able to draw mine down to almost 0. Good luck roll some coal....

I am gettting my Smarty and I am wondering what settings should i run

What year truck? Do you have an aftermarket lift pump?

For daily driving I keep mine on level 5, torque management 1, timing 4 and rail pressure 1.

MikeyB